Effect of CoO nanoparticles on the carbohydrate metabolism of the brain of mice "Mus musculus"

Shaikh, S.; Desai, P.V.

dc.contributor.author	Shaikh, S.
dc.contributor.author	Desai, P.V.
dc.date.accessioned	2015-06-03T09:01:41Z
dc.date.available	2015-06-03T09:01:41Z
dc.date.issued	2016
dc.identifier.citation	The Journal of Basic and Applied Zoology. 77; 2016; 1-7.	en_US
dc.identifier.uri	http://dx.doi.org/10.1016/j.jobaz.2015.12.003
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/1860
dc.description.abstract	The effect of CoO nanoparticles (NPs) on the brain of mice administered through gastrointestinal tract for a period of 30 days was studied. AAS analysis revealed that NPs administered orally were retained by cerebellum, cerebral cortex, medulla oblongata and olfactory bulb. This retention of nanoparticles by the brain promoted a significant increase in glucose, pyruvate, lactate and glycogen levels along with the concomitant increase in hexokinase, glucose 6 phosphatase, and lactate dehydrogense activities. However, a decrease in glucose 6 phosphate dehydrogenase activity was observed in the brain regions indicating a deterioration of the pentose phosphate pathway. Thus, the present study suggests that the CoO NPs affect the carbohydrate metabolism of the brain.
dc.publisher	Elsevier	en_US
dc.subject	Zoology	en_US
dc.title	Effect of CoO nanoparticles on the carbohydrate metabolism of the brain of mice "Mus musculus"	en_US
dc.type	Journal article	en_US