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Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune

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dc.contributor.author Kamat, S.P.
dc.contributor.author Menezes, J.C.
dc.contributor.author Siddhaye, B.M.
dc.contributor.author Paknikar, S.K.
dc.date.accessioned 2015-06-03T09:54:03Z
dc.date.available 2015-06-03T09:54:03Z
dc.date.issued 2008
dc.identifier.citation Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry. 47(10); 2008; 1597-1599. en_US
dc.identifier.uri http://nopr.niscair.res.in/handle/123456789/2256
dc.identifier.uri http://irgu.unigoa.ac.in/drs/handle/unigoa/2098
dc.description.abstract Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity. In the first route, methylative lactone ring opening of the coumarin 2 followed by catalytic hydrogenation of the cinnamyl double bond and subsequent PPA cyclization gives the methyl ether 5 of 1 which on demethylation gives 1 in excellent yield. Alternatively, catalytic hydrogenation of 2 followed by fusion with anhydrous AlCl(3) gives high yield of 1 just two steps. en_US
dc.publisher NISCAIR en_US
dc.subject Chemistry en_US
dc.title Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune en_US
dc.type Journal article en_US
dc.identifier.impf y


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