Synthesis and anti-microbial studies of (E)-oxoalk-2-enoic acids

Kurangi, R.; Kadam, H.K.; Tilve, S.G.; Kerkar, S.

dc.contributor.author	Kurangi, R.
dc.contributor.author	Kadam, H.K.
dc.contributor.author	Tilve, S.G.
dc.contributor.author	Kerkar, S.
dc.date.accessioned	2015-06-04T02:36:21Z
dc.date.available	2015-06-04T02:36:21Z
dc.date.issued	2010
dc.identifier.citation	Journal of Chemical and Pharmaceutical Research. 2(4); 2010; 83-89.	en_US
dc.identifier.uri	http://jocpr.com/vol2-iss4-2010/JCPR-2-4-83-89.pdf
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/2406
dc.description.abstract	(E)-4-Oxonon-2-enoic acid 1a is a fatty acid, isolated from the mycelium of Streptomyces olevaceus. Owing to its significant activity against various Gram-positive and Gram-negative strains and particularly Staphylococcus aureus ATCC 11632; it is an attractive target for structure-activity relationship. We report herein a straightforward synthesis of (E)-4-Oxonon-2-enoic acid 1a and its analogues in a single step using Wittig reaction. The antibacterial and antifungal activity assay of 1a and its analogues 1b-1g is presented.
dc.publisher	JOCPR PublicationJOCPR Publication	en_US
dc.subject	Chemistry	en_US
dc.title	Synthesis and anti-microbial studies of (E)-oxoalk-2-enoic acids	en_US
dc.type	Journal article	en_US