Dengue-2-virus-interacting polypeptides involved in mosquito cell infection

Paingankar, M.S.; Gokhale, M.D.; Deobagkar, D.N.

dc.contributor.author	Paingankar, M.S.
dc.contributor.author	Gokhale, M.D.
dc.contributor.author	Deobagkar, D.N.
dc.date.accessioned	2015-06-04T02:56:43Z
dc.date.available	2015-06-04T02:56:43Z
dc.date.issued	2010
dc.identifier.citation	Archives of Virology. 155(9); 2010; 1453-1461.	en_US
dc.identifier.uri	http://dx.doi.org/10.1007/s00705-010-0728-7
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/2506
dc.description.abstract	For the design of effective antiviral strategies, understanding the fundamental steps of the virus life cycle, including virus-host interactions, is essential. We performed a virus overlay protein binding assay followed by proteomics for identification of proteins from membrane fractions of A7 (Aedes aegypti) cells, C6/36 (Aedes albopictus) cells and the midgut brush border membrane fraction of Ae.aegypti mosquito that bind to dengue-2 virus. Actin, ATP synthase beta subunit, HSc 70, orisis, prohibitin, tubulin beta chain, and vav-1 were identified as dengue-2-virus-binding proteins. Our results suggest that dengue-2 virus exploits an array of housekeeping proteins for its entry in mosquito cells.	en_US
dc.publisher	Springer Verlag (Germany)	en_US
dc.subject	Zoology	en_US
dc.title	Dengue-2-virus-interacting polypeptides involved in mosquito cell infection	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y