Effect of ferrous sulphate on aspartate and alanine aminotransferases of brain of Tilapia mossambica

Abstract

Iron in the form of ferrous sulphate coming from sources such as mines, writing inks, blue pigments, dyeing industries, photography, medicine, deodorizers, disinfectants, fungicides and molluscides, etc., contributes in elevating ferrous sulphate of water bodies. The present study investigated the action of ferrous sulphate on the local fish Tilapia mossambica. Tilapia exposed to 0.001 g/L ferrous sulphate for 30 days showed reduction of cytosolic AST and ALT activities of cerebral cortex by 35.4 percent and 29.1 percent, respectively, while exposure to 0.01 percent ferrous sulphate promoted 49.2 percent and 38.4 percent reduction of AST and ALT activities. Similarly mitochondrial AST and ALT activities reduced by 50 percent and 34.8 percent, respectively on exposure to 0.001 g/L ferrous sulphate while 0 01 g/L ferrous sulphate promoted 51 percent and 47.8 percent reductions of AST and ALT activities at the end of 30 days, suggesting interference in the glutamate and protein metabolism of Tilapia brain.