Effect of dietary manipulation of lipids on mice, Mus musculus

Abstract

Dietary fatty acids play important role in various physiological processes and maintaining health. The beneficial effect of dietary fatty acids is hypothesized to depend upon its type, dose and duration of intake. Objective of this study was to find a particular dose and duration of intake of dietaiy fat which has the most beneficial effect. Experimental animal (Mus musculus) were administered fish oil and meat oil respectively in the form of 5, 10 and 20 percent doses blended with the pellet diet. Mice were sacrificed at the end of 30 and 60 days feeding period to collect blood, liver, kidney and heart tissues. Dietaiy intake of 10 percent fish oil for a period of 30 days maintained favourable tissue biochemical composition, hematological parameters, serum lipid and fatty acid profiles along with liver function tests when compared to that of meat oil. GC profiles showed more accumulation of eicosapentaenoic acid and docosahexaenoic acid in the tissues in contrast to that of meat oil where arachidonic acid was found to accumulate. Prolong intake of fish oil or higher doses of lipid might have negative effect. Results of our present study reveal a more beneficial effect of fish oil than meat oil in Mus musculus.