Fish lipid prevents alcohol induced damages in liver and kidney, tissues of mice (Mus musculus)

Abstract

The beneficial effect of dietary lipid is hypothesized to depend upon its type and composition, dose and duration of intake. The present study has been aimed to evaluate the ameliorative effect of two fish lipid, extracted from Sardinella longiceps and Rastrelliger kanagurta, in alcohol induced damages in liver and kidney tissue of mice, Mus musculus. Concentration of various biochemical parameters viz., total protein, albumin, total carbohydrate, urea, triglyceride, total and conjugated bilirubin, reduced glutathione (GSH) and Thiobarbituric acid reactive substances (TBARS) along with the activities the of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphates (ALP) and gamma glutamyl transpeptidase (GGT) were monitored in these tissues. Altered levels of tissue biochemical compositions and the increased activities of the studied enzymes due to alcohol toxicities were reverted with the supplementation of 10% fish lipids. Lipids from Sardinella longiceps brought the maximum changes in concentration of albumin, Bilirubin, triglycerides and in the activities of AST and GGT in comparison with the same of Rastrelliger kanagurta. Histological studies of liver and kidney confirms the protective effect of dietary fish lipid from alcohol toxicities.