Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa

Majik, M.S.; Naik, D.; Bhat, C.; Tilve, S.G.; Tilvi, S.; D'Souza, L.

dc.contributor.author	Majik, M.S.
dc.contributor.author	Naik, D.
dc.contributor.author	Bhat, C.
dc.contributor.author	Tilve, S.G.
dc.contributor.author	Tilvi, S.
dc.contributor.author	D'Souza, L.
dc.date.accessioned	2015-06-04T03:40:33Z
dc.date.available	2015-06-04T03:40:33Z
dc.date.issued	2013
dc.identifier.citation	Bioorganic and Medicinal Chemistry Letters. 23(8); 2013; 2353-2356.	en_US
dc.identifier.uri	http://dx.doi.org/10.1016/j.bmcl.2013.02.051
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/2877
dc.description.abstract	(R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. In this Letter, we have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat. hydrogenation as the key steps and its biological studies are reported for the first time. The synthesized norbgugaine was evaluated for inhibition of quorum sensing mediated virulence factors (motility, biofilm formation, pyocyanin pigmentation, rhamnolipid production and LasA protease) in Pseudomonas aeruginosa wherein swarming motility is reduced by 95 percent, and biofilm formation by 83 percent.	en_US
dc.publisher	Elsevier	en_US
dc.subject	Chemistry	en_US
dc.title	Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y