Graphite catalyzed solvent free synthesis of dihydropyrimidin-2(1H)-ones/thiones and their antidiabetic activity

Dhumaskar, K.L.; Meena, S.N.; Ghadi, S.C.; Tilve, S.G.

dc.contributor.author	Dhumaskar, K.L.
dc.contributor.author	Meena, S.N.
dc.contributor.author	Ghadi, S.C.
dc.contributor.author	Tilve, S.G.
dc.date.accessioned	2015-06-04T04:22:26Z
dc.date.available	2015-06-04T04:22:26Z
dc.date.issued	2014
dc.identifier.citation	Bioorganic and Medicinal Chemistry Letters. 24(13); 2014; 2897-2899.	en_US
dc.identifier.uri	http://dx.doi.org/10.1016/j.bmcl.2014.04.099
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/3052
dc.description.abstract	A solvent free three component condensation reaction between an aldehyde, ethyl acetoacetate and urea catalyzed by graphite, a green catalyst is described for the synthesis of dihydropyrimidin-2(1H)-ones. This protocol is scalable and the catalyst is reusable. This method is also applied for the synthesis of dihydropyrimidin-2(1H)-thiones. alpha-Amylase, a key enzyme in carbohydrate metabolism is generally targeted for management of type 2 diabetes. The therapeutic potential of the dihydropyrimidinones and dihydropyrimidinthiones to inhibit alpha-amylase activity was evaluated by in vitro assay. Of the synthesized compounds 3,4-dihydropyrimidin-2(1H)-thione (1k) demonstrated highest inhibition of alpha-amylase activity.	en_US
dc.publisher	Elsevier	en_US
dc.subject	Chemistry	en_US
dc.title	Graphite catalyzed solvent free synthesis of dihydropyrimidin-2(1H)-ones/thiones and their antidiabetic activity	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y