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Absorption, LD50 and Effects of CoO, MgO and PbO Nanoparticles on Mice "Mus musculus"

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dc.contributor.author Shaikh, S.M.
dc.contributor.author Shyama, S.K.
dc.contributor.author Desai, P.V.
dc.date.accessioned 2015-09-29T06:50:50Z
dc.date.available 2015-09-29T06:50:50Z
dc.date.issued 2015
dc.identifier.citation IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT). 9(2 (ver 1)); 2015; 32-38. en_US
dc.identifier.uri http://dx.doi.org/10.9790/2402-09213238
dc.identifier.uri http://irgu.unigoa.ac.in/drs/handle/unigoa/4095
dc.description.abstract Metal oxide nanoparticles (NPs) are widely used in the world for different purposes. This is the first report on the LD50 and the effects of CoO, MgO and PbO NPs on mice. LD50 for acute and 30 day's chronic dosage of these metal oxide NPs was calculated. Our results showed that the acute (single dose exposure) LD50 for CoO is 7835 mg/kg, MgO is 3954 mg/kg and PbO is 14,677 mg/kg of body weight. Whereas, the LD50 for 30 days chronic dosage for CoO is 1066 mg/kg, MgO is 1315 mg/kg and PbO is 634.88 mg/kg of body weight. The NPs were deposited in different tissues of mice when exposed to acute and chronic dosages of all afore mentioned three different NPs. The NPs were maximally absorbed by the muscles on acute and chronic exposure to CoO, MgO as well as PbO NPs. The chronic exposure of CoO, PbO and MgO led to changes in behavior, body weight and organ index of the mice. en_US
dc.subject Zoology en_US
dc.title Absorption, LD50 and Effects of CoO, MgO and PbO Nanoparticles on Mice "Mus musculus" en_US
dc.type Journal article en_US


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