First example of the cascade acylation/IMDAV/ene reaction sequence, leading to N-arylbenzo[f]isoindole-4-carboxylic acids possessing anti-viral activity

Voronov, A.A.; Alekseeva, K.A.; Ryzhkova, E.A.; Zarubaev, V.V.; Galochkina, A.V.; Zaytsev, V.P.; Majik, M.S.; Tilve, S.G.; Gurbanov, A.V.; Zubkov, F.I.

dc.contributor.author	Voronov, A.A.
dc.contributor.author	Alekseeva, K.A.
dc.contributor.author	Ryzhkova, E.A.
dc.contributor.author	Zarubaev, V.V.
dc.contributor.author	Galochkina, A.V.
dc.contributor.author	Zaytsev, V.P.
dc.contributor.author	Majik, M.S.
dc.contributor.author	Tilve, S.G.
dc.contributor.author	Gurbanov, A.V.
dc.contributor.author	Zubkov, F.I.
dc.date.accessioned	2018-03-01T08:59:06Z
dc.date.available	2018-03-01T08:59:06Z
dc.date.issued	2018
dc.identifier.citation	Tetrahedron Letters. 59(12); 2018; 1108-1111.	en_US
dc.identifier.uri	https://doi.org/10.1016/j.tetlet.2018.02.015
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5110
dc.description.abstract	The reaction between readily accessible N-aryl-3-phenylallylamines and maleic anhydride led to unexpected products – polysubstituted hydrogenated benzo[f]isoindole-4-carboxylic acids. This transformation proceeds through a previously unknown sequence of steps: N-acylation of the allylamine with maleic anhydride, intramolecular Diels-Alder reaction of the vinylarene in the intermediate N-maleamide, and Alder-ene reaction of the products of the previous two steps. Selected benzo[f]isoindoles displayed antiviral activity.	en_US
dc.publisher	Elsevier	en_US
dc.subject	Chemistry	en_US
dc.title	First example of the cascade acylation/IMDAV/ene reaction sequence, leading to N-arylbenzo[f]isoindole-4-carboxylic acids possessing anti-viral activity	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y