dc.contributor.author |
Kim, G. |
|
dc.contributor.author |
Yoon, J-S. |
|
dc.contributor.author |
Jarhad, D.B. |
|
dc.contributor.author |
Shin, Y.S. |
|
dc.contributor.author |
Majik, M.S. |
|
dc.contributor.author |
Mulamoottil, V.A. |
|
dc.contributor.author |
Qu, X.H.S. |
|
dc.contributor.author |
Park, J. |
|
dc.contributor.author |
Baik, M-H. |
|
dc.contributor.author |
Jeong, L.S. |
|
dc.date.accessioned |
2018-07-12T06:59:55Z |
|
dc.date.available |
2018-07-12T06:59:55Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
Organic Letters. 19; 2017; 5732-5735. |
en_US |
dc.identifier.uri |
http://dx.doi.org/10.1021/acs.orglett.7b02470 |
|
dc.identifier.uri |
http://irgu.unigoa.ac.in/drs/handle/unigoa/5324 |
|
dc.description.abstract |
(?)-6'-Beta-Fluoro-aristeromycin (2), a potent inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, has been synthesized via stereoselective electrophilic fluorination followed by a purine base build-up approach. Interestingly, purine base condensation using a cyclic sulfate resulted in a synthesis of (+)-5'-Beta-fluoro-isoaristeromycin (2a). Computational analysis indicates that the fluorine atom controlled the regioselectivity of the purine base substitution. |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.subject |
Chemistry |
en_US |
dc.title |
Asymmetric Synthesis of (?)-6'-Beta-Fluoro-aristeromycin via stereoselective electrophilic fluorination |
en_US |
dc.type |
Journal article |
en_US |
dc.identifier.impf |
y |
|