Asymmetric Synthesis of (?)-6'-Beta-Fluoro-aristeromycin via stereoselective electrophilic fluorination

Kim, G.; Yoon, J-S.; Jarhad, D.B.; Shin, Y.S.; Majik, M.S.; Mulamoottil, V.A.; Qu, X.H.S.; Park, J.; Baik, M-H.; Jeong, L.S.

dc.contributor.author	Kim, G.
dc.contributor.author	Yoon, J-S.
dc.contributor.author	Jarhad, D.B.
dc.contributor.author	Shin, Y.S.
dc.contributor.author	Majik, M.S.
dc.contributor.author	Mulamoottil, V.A.
dc.contributor.author	Qu, X.H.S.
dc.contributor.author	Park, J.
dc.contributor.author	Baik, M-H.
dc.contributor.author	Jeong, L.S.
dc.date.accessioned	2018-07-12T06:59:55Z
dc.date.available	2018-07-12T06:59:55Z
dc.date.issued	2017
dc.identifier.citation	Organic Letters. 19; 2017; 5732-5735.	en_US
dc.identifier.uri	http://dx.doi.org/10.1021/acs.orglett.7b02470
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5324
dc.description.abstract	(?)-6'-Beta-Fluoro-aristeromycin (2), a potent inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, has been synthesized via stereoselective electrophilic fluorination followed by a purine base build-up approach. Interestingly, purine base condensation using a cyclic sulfate resulted in a synthesis of (+)-5'-Beta-fluoro-isoaristeromycin (2a). Computational analysis indicates that the fluorine atom controlled the regioselectivity of the purine base substitution.	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Chemistry	en_US
dc.title	Asymmetric Synthesis of (?)-6'-Beta-Fluoro-aristeromycin via stereoselective electrophilic fluorination	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y