Synthesis of (-)-elemoxide, a commercially important fragrance compound

Rodrigues, L.; Majik, M.S.; Tilve, S.G.; Wahidulla, S.

dc.contributor.author	Rodrigues, L.
dc.contributor.author	Majik, M.S.
dc.contributor.author	Tilve, S.G.
dc.contributor.author	Wahidulla, S.
dc.date.accessioned	2018-09-06T04:40:38Z
dc.date.available	2018-09-06T04:40:38Z
dc.date.issued	2018
dc.identifier.citation	Tetrahedron Letters. 59(37); 2018; 3413-3415.	en_US
dc.identifier.uri	https://doi.org/10.1016/j.tetlet.2018.08.003
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5396
dc.description.abstract	(?)-Elemoxide, a fragrant compound was synthesised using commercially available elemol in four steps with overall yield of 32 percent. The cyclic ether skeleton was constructed via intramolecular hydroalkoxylation using I2 and PhSiH3 catalytic system. Also, intramolecular oxymercuration-demercuration was employed as an alternate approach for cyclization. The various regioselective strategies involving epoxidation of alkene, reduction of epoxide and intramolecular cyclization were the highlights of the work. The key intermediate diol serves as a versatile intermediate for the synthesis of elemoxide and elemene.	en_US
dc.publisher	Elsevier	en_US
dc.subject	Chemistry	en_US
dc.title	Synthesis of (-)-elemoxide, a commercially important fragrance compound	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y