Solventless mechanosynthesis of Bis(Indolyl)Methanes

Mhaldar, S.N.; Mandrekar, K.S.; Gawde, M.K.; Shet, R.V.; Tilve, S.G.

dc.contributor.author	Mhaldar, S.N.
dc.contributor.author	Mandrekar, K.S.
dc.contributor.author	Gawde, M.K.
dc.contributor.author	Shet, R.V.
dc.contributor.author	Tilve, S.G.
dc.date.accessioned	2019-02-14T04:27:39Z
dc.date.available	2019-02-14T04:27:39Z
dc.date.issued	2019
dc.identifier.citation	Synthetic Communications. 49(1); 2019; 94-101.	en_US
dc.identifier.uri	https://doi.org/10.1080/00397911.2018.1542732
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5590
dc.description.abstract	Ball-milling technique as a solvent-free and an alternative green process was investigated for the eco-benign synthesis of bis(indolyl)methanes (BIMs) from various aldehydes and selected ketones with indoles in high yields. The present methodology has several advantages such as simple procedure, good yields, mild conditions, and reduced environmental consequences. The silica gel acts both as a grinding medium and an acid catalyst. The utility of this technique was demonstrated by synthesizing library of 17 BIMs including two natural products trisindoline and tris(1H-indol-3-yl)methane.	en_US
dc.publisher	Taylor & Francis	en_US
dc.subject	Chemistry	en_US
dc.title	Solventless mechanosynthesis of Bis(Indolyl)Methanes	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y