Enhancing the anti-tyrosinase activity of a hypersaline Kitasatospora sp. SBSK430 by optimizing the medium components

Fernandes, M.S.; Kerkar, S.

dc.contributor.author	Fernandes, M.S.
dc.contributor.author	Kerkar, S.
dc.date.accessioned	2019-03-08T08:48:05Z
dc.date.available	2019-03-08T08:48:05Z
dc.date.issued	2019
dc.identifier.citation	Current Science. 116(4); 2019; 649-653.	en_US
dc.identifier.uri	https://www.currentscience.ac.in/Volumes/116/04/0649.pdf
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5609
dc.description.abstract	Tyrosinase inhibitors from natural resources have been gaining importance in pharmaceutical and horticultural applications. A full factorial central composite design was used to study the interactive effect of three variables, i.e. D-mannitol, yeast extract and sodium chloride of the fermentation medium for maximizing anti-tyrosinase activity (75.5 percent) of a hypersaline actinobacteria, Kitasatospora sp. SBSK430. A quadratic model was found to fit the anti-tyrosinase activity (R sup(2) = 0.948). Response surface analysis revealed that the optimum values of the medium components were 15 g/l D-mannitol, 5.6 g/l yeast extract and 1.2 g/l sodium chloride. Tyrosinase inhibition activity was enhanced 1.1-fold, using this approach.	en_US
dc.publisher	Current Science Association	en_US
dc.subject	Biotechnology	en_US
dc.title	Enhancing the anti-tyrosinase activity of a hypersaline Kitasatospora sp. SBSK430 by optimizing the medium components	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y