Frontiers in developmental neurogenesis (Chapter 23)

Abstract

Early embryonic neurogenesis is characterized by proliferation, differentiation, migration, and spatial arrangement of progenitor cells that direct the architecture of developing the nervous system. This is carried out by intrinsic determinant and extrinsic signals that influence progenitor cells maintaining temporal and spatial boundaries during developmental neurogenesis. This review attempts to put forth some of the recent understandings and methodological tools for studying novel insights of signaling that occur during developmental neurogenesis. The first half of this review entails some of the important molecules involved in signaling pathway cross talk of developmental neurogenesis, and the second half deals with various upcoming methodological tools with in vitro models to carryout frontier research in the field of developmental neurogenesis that will create many more fundamental insights and opportunities with important applications in biomedicine and biotechnology.