Iodine-DMSO-catalyzed chemoselective biomimetic aromatization of tetrahydro-beta-carbolines-3-carboxylic Acid: Mechanism study with DFT-calculation

Gaikwad, S.V.; Nadimetla, D.N.; Kobaisi, M.A.; Devkate, M.; Joshi, R.; Shinde, R.G.; Gaikwad, M.V.; Nikalje, M.D.; Bhosale, S.V.; Lokhande, P.D.

dc.contributor.author	Gaikwad, S.V.
dc.contributor.author	Nadimetla, D.N.
dc.contributor.author	Kobaisi, M.A.
dc.contributor.author	Devkate, M.
dc.contributor.author	Joshi, R.
dc.contributor.author	Shinde, R.G.
dc.contributor.author	Gaikwad, M.V.
dc.contributor.author	Nikalje, M.D.
dc.contributor.author	Bhosale, S.V.
dc.contributor.author	Lokhande, P.D.
dc.date.accessioned	2019-09-17T04:41:42Z
dc.date.available	2019-09-17T04:41:42Z
dc.date.issued	2019
dc.identifier.citation	ChemistrySelect. 4(34); 2019; 10054-10059.	en_US
dc.identifier.uri	https://doi.org/10.1002/slct.201902419
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/5851
dc.description.abstract	A new protocol for the chemoselective aromatization of tetrahydro-beta-carboline-3-carboxylic acids to direct biomimetic one step synthesis of beta-carboline-3-carboxylic acids 2 A-L using catalytic amount of I sub(2) in DMSO/H sup(+) produces very good yield. This method was also successfully extended for the aromatization of tetrahydro-beta-carboline-3-methyl esters 5 A-G as well as one-step synthesis of Marinacarbolines-D analog, respectively. Further, the mechanism and role of iodine-DMSO in aromatization has been studied by Density Functional Theory Calculation.	en_US
dc.publisher	Wiley	en_US
dc.subject	Chemistry	en_US
dc.title	Iodine-DMSO-catalyzed chemoselective biomimetic aromatization of tetrahydro-beta-carbolines-3-carboxylic Acid: Mechanism study with DFT-calculation	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y