Estimation of cholesterol in the presence of urea and other constituents in blood tissue

Abstract

The determination of cholesterol in pathological laboratories is more painful and may lead to infections if no proper precautions are taken into consideration. The manuscript presented here describes a non-invasive method to estimate blood cholesterol using Radio Frequency (RF) probe signal in the range of 10MHz - 500MHz. The method uses Scalar Network Analyzer and injects RF signal less than -30dbm, which is quite safe for human tissue and the frequency range falls in non-ionizing radiation wavelengths. Due to the absorption of RF signal by various body tissues including cholesterol, the received signal by the spectrum analyzer bears the signatures of percentage of the cholesterol present in the blood. These signatures are then analyzed using multivariate approach to estimate the Cholesterol. The Signal Processing Unit consists of Partial Least Square Regression (PLSR) tool based on the SIMPLS Algorithm. The results show that there is a good agreement between the predicted percentages of Cholesterol as compared to the actual. Though the study here uses only 5 components, the technique can also be used to include other blood components for the estimation of Cholesterol.