dc.contributor.author |
Wagalgave, S.M. |
|
dc.contributor.author |
Padghan, S.D. |
|
dc.contributor.author |
Kobaisi, M.A. |
|
dc.contributor.author |
La, D.D. |
|
dc.contributor.author |
Bhamidipati, K. |
|
dc.contributor.author |
Puvvada, N. |
|
dc.contributor.author |
Bhosale, R.S. |
|
dc.contributor.author |
Bhosale, Sidhanath V. |
|
dc.contributor.author |
Bhosale, S.V. |
|
dc.date.accessioned |
2020-10-07T03:36:01Z |
|
dc.date.available |
2020-10-07T03:36:01Z |
|
dc.date.issued |
2020 |
|
dc.identifier.citation |
New Journal of Chemistry. 44(41); 2020; 18092-18101. |
en_US |
dc.identifier.uri |
https://doi.org/10.1039/D0NJ01235A |
|
dc.identifier.uri |
http://irgu.unigoa.ac.in/drs/handle/unigoa/6229 |
|
dc.description.abstract |
The molecular building block NDI-LCA was synthesized by substitution of NDA at di-imide position with two lithocholic acid moieties. It was found that the NDI-LCA conjugate exhibits good thermal stability. The photophysical such as UV-vis and fluorescence spectral measurements and theoretical calculations reveal that NDI-LCA possesses stronger absorption and fluorescence emission properties. Furthermore, NDI-LCA derivative self-assembled into chiral flower-like structures in THF/MCH solvent mixture, whereas, NDI-LCA in THF/water produces chiral fibril nanostructures. The formation of supramolecular self-assembly in solution was characterization by UV-vis, fluorescence spectroscopy, and dynamic light scattering (DLS). Circular dichroism is used to study chiral induction in supramolecular structures. Scanning Electron Microscopy (SEM) confirms the formed structure on the silicon wafer. X-ray diffraction (XRD) clearly shows the formation of the crystalline nature of morphology. In addition, NDI-LCA's supramolecular structures in THF exhibit remarkable bio-compatibility and increased cellular uptake in cancer cells. From cell morphology and uptake studies, it can be assumed that NDI-LCA in THF supramolecular structures can act effectively as a platform for both cell markers and as a delivery agent for further studies. |
en_US |
dc.publisher |
Royal Society of Chemistry |
en_US |
dc.subject |
Chemistry |
en_US |
dc.title |
Selectivity and bio-compatibility of self-assembled chiral flower-like and helical nanostructures |
en_US |
dc.type |
Journal article |
en_US |
dc.identifier.impf |
y |
|