Progestin (Norethisterone) induced genetic damage in mouse bone marrow

Shyama, S.K.; AbdulRahiman

dc.contributor.author	Shyama, S.K.
dc.contributor.author	AbdulRahiman
dc.date.accessioned	2015-06-03T06:39:04Z
dc.date.available	2015-06-03T06:39:04Z
dc.date.issued	1993
dc.identifier.citation	Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 300(3and4); 1993; 215-221.	en_US
dc.identifier.uri	http://dx.doi.org/10.1016/0165-1218(93)90053-G
dc.identifier.uri	http://irgu.unigoa.ac.in/drs/handle/unigoa/637
dc.description.abstract	Primolut-N tablets containing norethisterone were assessed for their in vivo genotoxic effect on the bone marrow cells of Swiss albino mice. The chromosomal aberration assay and the micronucleus test were employed for the study. Statistically significant increases in chromosomal aberrations were induced by doses more than or equal to 3.0 mg/kg/day. The maximum frequency of aberrations was induced at 24 h, thereafter decreasing with increasing time. But the drug Primolut-N did not induce a significant increase in the number of micronuclei in bone marrow erythrocytes at any of the doses and time intervals studied.	en_US
dc.publisher	Elsevier	en_US
dc.subject	Zoology	en_US
dc.title	Progestin (Norethisterone) induced genetic damage in mouse bone marrow	en_US
dc.type	Journal article	en_US
dc.identifier.impf	y