Effect of CoO nanoparticles on the enzyme activities and neurotransmitters of the brain of the mice "Mus musculus"

Abstract

The effects of CoO Nanoparticles (NPs) on the brain enzymes and neurotransmitters of the mice were studied. The NPs were fed orally to the mice for a period of 30 days. The chronic (30 days) exposure of mice to NPs exhibited decrease in ALP, SGPT, SGOT, glutamate dehydrogenase and acetyl cholinesterase activities and increase in ACP and glutamine synthetase activity dose dependently. Further it also caused significant dose dependent decrease in the dopamine, Serotonin, GABA, Glutamate and Acetylcholine levels. These alterations in the electrolyte and neurotransmitter concentrations as well as enzyme activities of the brain could affect the metabolism, signal transduction and change the acid base balance of the brain leading to the impairment of the brain functions.