Abstract:
Phthalocyanines (Pcs) being analogous to naturally occurring Porphyrins and having the ability of generating singlet oxygen, are under incessant studies for their activity in Photodynamic Therapy (PDT) and antimicrobial activity. Water soluble Pcs are of enormous importance for this category of activity. Pcs show extensive variation in properties with change in the substitution at the peripheral position and also the central metal atom. The synthesis of a novel water soluble Manganese tetra (n-carbonylacrylic) aminephthalocyanines (MnTCPc) and antimicrobial activity against bacteria strains, such as Escherichia coli (ATCC 8739), Salmonella typhi (ATCC 14028), Pseudomonas aeruginosa (ATTC 9027), Bordetella bronchiseptica (ATCC 4617), Staphylococcus epidermidis (ATCC 12228) and Bacillus subtilis (ATCC 6633) have been discussed. The effect of solvent on the antimicrobial activity is noticed and the probable mode for the destruction of the cell wall based on the generation of single oxygen.
