Tandem approaches for the synthesis of functionalized pyrrolidones: Efficient routes toward allokainic acid and kainic acid

Bhat, C.; Tilve, S.G.

Tandem approaches for the synthesis of functionalized pyrrolidones: Efficient routes toward allokainic acid and kainic acid

Bhat, C.; Tilve, S.G.

Source : Tetrahedron Letters. 54(3); 2013; 245-248.

URI: http://dx.doi.org/10.1016/j.tetlet.2012.11.007
http://irgu.unigoa.ac.in/drs/handle/unigoa/2868

Date: 2013

Document Type: Journal article

Abstract:

Tandem approaches for the synthesis of pyrrolidone precursor of allokainic acid and kainic acid are described. The synthesis of pyrrolidone intermediate of allokainic acid is achieved by tandem Wittig-Michael reaction and tandem amidation-Michael reaction while one pot amidation-Ene-esterification is employed for the synthesis of Ganem intermediate (2:1) of kainic acid.

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