Synthesis of 6H-Isoindolo[2,1-a]indol-6-ones through Wittig reaction and tandem reductive cyclization-lactamization

Kadam, H.K.; Tilve, S.G.

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Synthesis of 6H-Isoindolo[2,1-a]indol-6-ones through Wittig reaction and tandem reductive cyclization-lactamization

Kadam, H.K.; Tilve, S.G.

Source : European Journal of Organic Chemistry. 2013(20); 2013; 4280-4284.

URI: http://dx.doi.org/10.1002/ejoc.201300047
http://irgu.unigoa.ac.in/drs/handle/unigoa/2874

Date: 2013

Document Type: Journal article

Abstract:

A convenient and efficient two-step route to 6H-Isoindolo[2,1-a]indol-6-ones has been developed starting from o-nitrobenzaldehydes. The methodology involves Wittig reaction followed by tandem reductive cyclization-lactamization. A series of isoindoloindolones incorporating different substituents on the indole nucleus has been prepared.

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