Protecting-group-directed regio- and stereoselective oxymercuration–demercuration: Synthesis of piperidine alkaloids containing 1,2- and 1,3-amino alcohol units

Abstract

An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l-pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration–demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.