Tandem Wittig - Reductive annulation decarboxylation approach for the synthesis of indole and 2-substituted indoles

Volvoikar, P.S.; Tilve, S.G.

Tandem Wittig - Reductive annulation decarboxylation approach for the synthesis of indole and 2-substituted indoles

Volvoikar, P.S.; Tilve, S.G.

Source : Tetrahedron Letters. 59(19); 2018; 1851-1854.

URI: https://doi.org/10.1016/j.tetlet.2018.04.001
http://irgu.unigoa.ac.in/drs/handle/unigoa/5187

Date: 2018

Document Type: Journal article

Abstract:

A simple tandem Wittig reaction-reductive decarboxylation route is established for the synthesis ofindoles from commercially available o-nitrobenzaldehydes and a stable phosphorane. The method allowsaccess to indoles in a very fast manner without involving any metal or expensive reagents or inert atmo-sphere. Also 2-substituted indoles are obtained which forms an important core of many biological activecompounds.

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