1,6-Addition of 1,2,3-NH triazoles to para-quinone methides: Facile access to highly selective N sup(1) and N sup(2) substituted triazoles

Abstract

The regioselective syntheses of N sup(1) and N sup(2) substituted triazoles through a 1,6-addition reaction of 1,2,3-NH triazoles to p-quinone methide were achieved under mild reaction conditions. The present reactions showed superior results in terms of selectivity, mild reaction conditions, short reaction time and broad substrate scope with good functional-group compatibility. Considering the high synthetic value of N sup(1)- and N sup(2)-substituted compounds and p-QM related research, the present strategy will greatly benefit researchers in various fields.