Quantitative evaluation of the electronic features involving "nucleophilic-electrophilic" character in the chalcogen sulfur

Abstract

This study investigates the crystal structures of substituted thiophenes and isothiocyanates by utilizing the method of in situ cryocrystallization to gain quantitative insights into the electronic features of sulfur-centered interactions. This work reveals that the role of sulfur as a "nucleophilic" or "electrophilic" species during non-covalent interaction is significantly influenced by its immediate chemical and electronic surroundings.