Efficacy of nonantimicrobial drugs against Enterococcus faecalis using confocal laser scanning microscopy - An in vitro study

Abstract

Enterococcus faecalis is a key contributor to persistent endodontic infections and often shows resistance to conventional medicaments such as calcium hydroxide. Growing antimicrobial resistance has led to interest in repurposing nonantibiotic drugs such as nonsteroidal anti-inflammatory drugs and proton-pump inhibitors that have shown promising antimicrobial effects against E. faecalis. The study aimed to evaluate the in vitro antibiofilm activity of different combinations of nonantimicrobial drugs with and without calcium hydroxide against E. faecalis.