Genotoxicity of Lynoral (ethinyloestradiol, an oestrogen) in mouse bone marrow cells, in vivo

Abstract

The genotoxic effect of Lynoral (ethinyloestradiol, an oestrogen) was studied using mouse bone marrow cells treated in vivo, employing a chromosomal aberration assay and micronucleus test. The dose and time-yield effects of the sex hormonal drug were investigated. Lynoral failed to induce significant genetic damage in the bone marrow erythrocytes of mice, regarding chromosomal aberrations and micronuclei.